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Thursday, September 6, 2012

Medical Manufacturing: Air Purification Options


Watching Oscar Pistorius sprint on prosthetic legs can make modern medical devices appear far removed from more traditional manufactured products.

Certainly, it can be difficult to connect the production of Oscar’s blades or high-tech devices that aid cataract surgery, for example, to the manufacture of metal brackets or kitchen sinks.

Yet, both medical device and traditional manufacturers must develop good manufacturing practices (GMP) that include appropriate, designed-in user interfaces, adherence to  regulations, and quality assurance processes that include worker health and user safety.

When it comes to medical device fabrication, a key concern of the Federal Drug Administration (FDA) is contamination, so regulations address a range of issues, including building design, employee training, and environmental controls.

4 Sentry Air customers

This blog profiles 4 customers who desired clean air in their manufacture of medical products and the Sentry Air products that solved their problems.

1-Epoxy and adhesive fume control

Bulow Biotech Prosthetics fabricates functional and cosmetic prostheses for individuals who suffered amputation of an extremity.

They produce their custom prosthetics, using epoxies and adhesives that off-gas, in a typical office building where installation of a ducted fume ventilation system was bid at over $23,000.

Instead of going that route, Bulow Biotech purchased a Sentry Air Model 400 Dual Arm Fume Extractor and positioned it on a shelf over the adhesives work bench.

Sentry Air Model 400 Dual Arm fume extractor is positioned over the adhesives work bench.

"The Model  SS-400-FSD unit is a fraction of [a ducted ventilation system], 
is very quiet and works so well that it is difficult to smell any trace of chemical 
in our laminating room where all resins and adhesives are used,” 
Kirk Simendinger, Certified Prosthetist. 
[Photo: Bulow Biotech Prosthetics]


The Model SS-400-FSD is typically equipped with heavy-duty casters and flex-arms capable of 360 degree rotation and is used in a variety of medical and industrial applications.

2-Extracting adhesive and solvent fumes

A manufacturer of equipment for MRI systems used two Sentry Air dual-arm fume extractors to improve process flow. Process flow is a key consideration of GMP because it defines key process steps and affects workers, equipment and materials.

They use one Model # SS-450-FSD Dual-Arm Fume Extractor to captures fumes created in their adhesive application process and a second unit to remove strong fumes created in their cleaning process.

Sentry Air Model 450 fume extractor with dual arms and dimensions noted in inches.
"Prior to using the Model 450, our adhesive application process 
was located far from our production line because the fumes were 
very strong. The use of the Model 450 allowed us to move the 
process back to our production line and has dramatically 
improved process flow.”

3-Dust Control

Argentum Medical, LLC produces products that use silver-coated fabric, used in the treatment of wounds, burns and some surgical procedures. They wanted to reduce the particulate count, produced primarily by the fabric in use, in their production facilities.

They chose two Model 2000 Free-Hanging Air Cleaners. These ambient-air, dual-stage filtration systems reduced particle counts by as much as 90%.

Sentry Air ceiling-mounted Model 2000 air purifier for medical manufacturing application.

After installing the Sentry Air free hanging system my 
worries were over. The particulate count has not  been over 
500,000 and most of the time it is below 300,000,"
Jeanette Cantrell, Operations Manager.

In GMP guidance for medical products manufacturers, the FDA regulations address the reduction of particulate contamination throughout Section 6 Buildings and Environment.

4-Biomaterial manufacturing via cell culturing

Ecovative Design makes products for shipping, construction and automobile manufacturing from agricultural by-products and fungi. That’s right: they use mushrooms and the inedible parts of farm crops to produce biomaterials that can replace petroleum-based foams.

Their products are not medical products, but their manufacturing processes require similar high standards for contamination control.

The FDA provides GMP design examples that limit opportunities for contamination. At Sentry Air, where clean air for workers and products is our full-time endeavor, we especially like this solution:

“A small laminar flow unit and curtains can create a small, but very clean area.”


At Ecovative Designs, our Portable Clean Rooms and Ductless Fume Hoods provide the sanitary work spaces necessary for culturing fungal cells and preparing media.

Two 40-inch wide Sentry Air hoods; portable clean room on the left, a ductless fume hood on the right.

"The Sentry Air Systems ductless hoods provided an ideal solution, 
rapidly delivering a complete laminar flow hood that continues 
to perform even years after the original purchase,” 
Gavin McIntyre, Ecovative Designs.

Sentry Air hoods are designed to fit on standard countertops.
Like all Sentry Air standard hoods, the SS-340-PCR fits 
on a standard work bench; no additional furniture is 
required. [Photo not related to Ecovative Designs]

For information on sanitary work space options for your medical or biological manufacturing process, give us a call at 1.800.799.4609, email us at sales@sentryair.com, or fill out this online form to have a Sentry Air Systems’ Applications Specialist contact you to discuss your process.




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